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| Description |
The Human NFκB Signaling Pathway
SureSilencing siRNA Array knocks down the expression of 42 key genes
related to NFκB-mediated signal transduction. The array includes
genes that encode members of the Rel, NFκB, and IκB families, NFκB-responsive
genes, receptors and adaptor proteins that activate the pathway, and
kinases and transcription factors that propagate the signal. NFκB-mediated
signal transduction has been implicated in the regulation of viral
replication, autoimmune diseases, the inflammatory response, tumorigenesis
and apoptosis. Using RNA Interference and the cell-based phenotypic assay
in your lab, you can easily and reliably evaluate the function of a
focused panel of genes related to NFκB signaling with this array.
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| Product Resources |
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| Related Products for the Genes on This Array |
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| Functional Gene Groupings |
Activation of the NFκB Pathway:
Ligands and Receptors: MYD88, TLR1, TLR2, TLR3, TLR4, TNFRSF10A,
TNFRSF10B, TRAF2.
Kinases: CHUK (IKK-α ), IKBKB (IKK-β), IKBKG (IKK-γ), IRAK2, MAP3K7
(TAK1), PRKCQ.
IκB Kinase/NFκB Cascade: IKBKG (IKK-γ), IRAK2.
Cytoplasmic Sequestering / Release of NFκB: NFKBIA (IκBα / mad3).
Transcription Factors: IKBKB (IKK-β), IKBKG (IKK-γ), IRAK1, NFKB1,
NFKBIA (IκBα / mad3), RELA.
Inflammatory Response: IRAK2, MYD88, NFKB1, TLR1, TLR2, TLR3, TLR4.
Positive Regulation of IκB Kinase and the NFκB Signaling Cascade:
Ligands and Receptors: LTBR, CD40, TICAM2, TNFRSF1A.
Kinases: IKBKE (IKK-i), MAP3K3, RIPK1 (RIP).
Others: BCL10, FADD, MALT1, TICAM1, TRADD, TRAF6.
Other Factors Involved in the NFκB Pathway:
Ligands and Receptors: EGFR, IGF1R, IL1R1, TRAF3.
Kinases: AKT1, MAP3K1 (MEKK1), PIK3CG.
Transcription Factors: ELK1, NFKB2, NFKBIB, RELB.
Inflammatory Response: IL1R1. |
| What is a SureSilencing siRNA Array? |
| The SureSilencing siRNA Arrays are the most
convenient tools for knocking down the expression and exploring the function
of a focused panel of genes in signal transduction pathways and biological
processes. The siRNA Arrays can be used for cancer, immunology, signal
transduction, toxicology, and many other areas of biological and medical
research.
Need more information about PCR Array Products? Please SureSilencing
siRNA Array home page or send Email to Technical Support
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| Storage Conditions |
| Please check the kit components immediately after you receive this package. SuperArray is only responsible for missing items reported within two (2) business days of receipt.
Storage Conditions: SureSilencing siRNA Arrays are
shipped at ambient temperature. Keep plates at 4 ºC for
long-term storage. The arrays are stable for six (6) months at the
recommended temperature. Do not use kit beyond the expiration date
printed on the label.
This product is made under license from The Carnegie Institution of Washington. However, the purchase of this material by a non-academic or for-profit organization will require a license to use the material from Carnegie. License queries may be directed to Gloria Brienza or Gary Kowalczyk at The Carnegie Institution of Washington, 1530 P Street NW, Washington, DC 20005.
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