Oligo GEArray® Mouse Genome Stability / DNA Repair Microarray: OMM-042
  
Description
The Oligo GEArray® Mouse Genome Stability & DNA Repair Microarray is designed to profile the expression of mouse genes known to be associated with maintaining genome stability. In mammalian cells, a network of biochemical pathways exists to maintain the functional and structural integrity of genome. The DNA repair system (including base, nucleotide, and mismatch excision) is a one of the major defense mechanisms cells use to minimize DNA mutations, damage, and replication errors. With the OMM-042 Oligo GEArray® Mouse Genome Stability & DNA Repair Microarray you can compare your experimental samples with expression data from a manageable number of related genes.

Need more information about GEArray products? please visit Microarray Home or send Email to Technical Support
Useful Links
Pricing and Ordering Gene Table GEArray Service
User Manual White Paper GEArray ThermoShaker
Related Products for the Genes on This Array
shRNA Plasmids qPCR Gene Assays Modify This Array
Functional Gene Grouping

DNA Damage Repair:

Base-excision repair: Adprt1, Adprtl2, Mbd4, Mpg, Mutyh, Nthl1, Ogg1, Rad51l3.
Nucleotide Excision Repair: Ercc2, Ercc3, Ercc5, Gtf2h3, Nthl1, Poll, Rad23a, Rad23b, Slk, Xpa, Xpc.
Mismatch Excision Repair: Mlh1, Mlh3, Msh2, Msh3, Msh4, Msh5, Msh6, Pms1, Pms2, Pold3, Trex1.
DSB Repair: Brca2, G22p1, Mre11a, Prkdc, Rad52, Xrcc4, Xrcc5.
RAD6-dependent pathway: Ube2a, Ube2b, Ube2i, Ube2n, Ube2v2.
Other DNA-repair related genes: Apex1, Apex2, Atm, Atr, Brca1, Dmc1h, Ercc1, Ercc4, Exo1, Fen1, Gtf2h1, Gtf2h2, Gtf2h4, Hus1, Lig1, Lig3, Lig4, Mgmt, Mus81, Nbn, Neil1, Polb, Rad18, Rad21, Rad50, Rad51, Rad51c, Rad51l1, Tdg, Ung, Xab2, Xrcc1, Xrcc2, Xrcc3.

Genome stability:

Telomere maintenance: Adprt1, Hnrpd, Pinx1, Tep1, Terf1, Terf2, Terf2ip, Tert, Tinf2.
Other genome-stability related genes: ATM, TOP3A, TOP3B.

Other genome stability or DNA repair related genes:

Adprtl3, Ankrd17, B3bp, Blm, Brip1, Ccnh, Cdk7, Cetn2, Cib1, Ckn1, Ddb1, Ddb2, Ercc6, Mjd, Mms19l, Mnat1, Neil2, Pnkp, Rad54l, Recc1, Recql4, Recql5, Rpa1, Rpa3, Smug1, Tnks, Tnks1bp1, Top3a, Top3b, Trp73.
Storage Conditions
Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References
  1. Trends in Biochemical Sciences (TIBS) 20 (10): October 1995 (237): 381-440
  2. Friedberg, E.C., Walker, G.C., and Siede, W. DNA repair and mutagenesis, Washington, D.C.ASM Press, 1995: 1-698.
  3. Hoege, C., B. Pfander, et al. (2002). RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419 (6903): 135-41.
  4. Richard D. Wood, Michael Mitchell, John Sgouros, Tomas Lindahl. (2001). Human DNA Repair Genes. Science 291:1284-1289.
  5. de Wind, N. and J. B. Hays (2001). Mismatch repair: praying for genome stability. Curr Biol 11 (14): R545-8.
  6. Ronen, A. and B. W. Glickman (2001). Human DNA repair genes. Environ Mol Mutagen 37 (3): 241-83.
  7. JAN H. J. HOEIJMAKERS (2001). Genome maintenance mechanisms for preventing cancer. Nature 411, 366 - 374.
  8. McEachern, M. J., Krauskopf, A. & Blackburn, E. H. (2000). Telomeres and their control. Annu. Rev. Genet. 34, 331-358.
  9. Haber, J. E. (2000). Partners and pathways repairing a double-strand break. Trends Genet. 16, 259-264
  10. Scully, R. & Livingston, D. M. (2000). In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408, 429-432.
  11. Khanna, K. K. & Jackson, S. P. (2001). DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genet. 27, 247-254.
Usefullink
Microarray Home
Cataloged Microarrays
Pricing and Ordering
User Manual
Gene Table
White Paper
  PCR Primers  
  Citations  
Product Support
How It Works
Download Brochure
  Technical Resources  
  Slide Presentation  
  Register for Web Seminar  
Copyright © 2008 SABiosciences Corporation