Oligo GEArray® Mouse Apoptosis Microarray

HybTube Format Cat. No.: OMM-012
HybPlate Format Cat. No.: EMM-012 		 
Description
The Oligo GEArray® Mouse Apoptosis Microarray profiles the expression of 112 genes involved in apoptosis. This array includes TNF ligands and their receptors, members of the bcl-2 gene family and caspases. Also represented are members of the IAP, TRAF, CARD, and death domain gene families. Death effector domain family members, CIDE domain family members, and genes involved in the p53 and DNA damage response pathways are included. The array also represents genes involved in anti-apoptosis. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples.

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Functional Gene Grouping

TNF Ligand Family: Tnf, Tnfsf10, Tnfsf12, Tnfsf14, Tnfsf5, Tnfsf6, Tnfsf7.

TNF Receptor Family: Ltbr, Tnfrsf10b, Tnfrsf11b, Tnfrsf12a, Tnfrsf14, Tnfrsf1a, Tnfrsf21, Tnfrsf22, Tnfrsf5, Tnfrsf6.

Bcl-2 Family: Bad, Bag1, Bag3, Bag4, Bak1, Bax, Bcl2, Bcl2l1, Bcl2l2, Bcl2l10, Bcl2l11, Bcl2l13, Bcl2l14, Bid, Bnip2, Bnip3, Bnip3l, Bok, Mcl1.

Caspase Family: Casp1, Casp2, Casp3, Casp4, Casp6, Casp7, Casp8, Casp8ap2, Casp9, Casp12, Casp14.

IAP Family: Birc1a, Birc1b, Birc1e, Birc1f, Birc2, Birc3, Birc4, Birc5, Birc6.

TRAF Family: Traf1, Traf2, Traf3, Traf4, Traf5.

CARD Family: Apaf1, Asc, Bcl10, Birc3, Birc4, Card4, Card6, Card10, Card11, Card14, Card15, Casp1, Casp2, Casp4, Casp9, Cradd, Nol3, Ripk1, Ripk2, Ripk3.

Death Domain Family: Cradd, Dapk1, Dapk2, Fadd, Ripk1, Tnfrsf10b, Tnfrsf11b, Tnfrsf1a, Tnfrsf21, Tnfrsf6.

Death Effector Domain Family: Casp8, Cflar, Fadd.

CIDE Domain Family: Cidea, Cideb, Dffa, Dffb.

p53 and DNA Damage-Induced Apoptosis: Akt1, Apaf1, Bad, Bax, Bcl2, Bcl2l1, Bid, Casp3, Casp6, Casp7, Casp9, Trp53, Trp53bp2, Trp53inp1, Trp63, Trp73.

Anti-Apoptosis: Akt1, Als2cr2, Api5, Atf5, Aven, Bag1, Bag3, Bag4, Bcl2, Bcl2l1, Bcl2l10, Bcl2l2, Birc1a, Birc1b, Birc1e, Birc1f, Birc2, Birc3, Birc4, Birc5, Birc6, Bnip2, Bnip3, Casp2, Cflar, Dad1, Dsip1, Faim, Hells, Il10, Il31ra, Lhx4, Mapk8ip, Mcl1, Nfkb1, Nipa, Nme5, Pak7, Pim2, Polb, Prdx2, Prlr, Prok2, Rnf7, Sphk2, Tnf, Tnfrsf6, Tnfsf5.

Storage Conditions
Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References
  1. Green, DR. (2000) Apoptotic Pathways: Paper Wraps Stone Blunts Scissors. Cell 102: 1-4.
  2. Salvesen GS, Dixit VM. (1999) Caspase Activation: The Induced-Proximity Model. PNAS 96: 10964-7.
  3. Nagata S (1999) Fas Ligand-Induced Apoptosis. Annu Rev Genet 33: 29-55.
  4. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. (1999) Biochemical Pathways Of Caspase Activation During Apoptosis. Annu Rev Cell Dev Biol 15: 269-90.
  5. Ekert PG, Silke J, Vaux DL (1999) Caspase Inhibitors. Cell Death Differ 6(11): 1081-6.
  6. Lutz RJ (2000) Role Of The BH3 (Bcl-2 Homology 3) Domain In The Regulation Of Apoptosis And Bcl-2-Related Proteins. Biochem Soc Trans 28 (2): 51-6.
  7. Inoue Ji, Ishida T, Tsukamoto N, Kobayashi N, Naito A, Azuma S, Yamamoto T. (2000) Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Family: Adapter Proteins That Mediate Cytokine Signaling. Exp Cell Res 254(1): 14-24.
  8. Deveraux QL, Stennicke HR, Salvesen GS, Reed JC (1999) Endogenous Inhibitors Of Caspases. J Clin Immunol 19(6): 388-98.
  9. Orlinick JR, Chao MV. (1998) TNF-Related Ligands And Their Receptors. Cell Signal 10(8): 543-51.
  10. Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME (1998) Apoptosis Signaling By Death Receptors. Eur J Biochem 254(3): 439-59.
  11. Singh A, Ni J, Aggarwal BB (1998) Death Domain Receptors And Their Role In Cell Demise. J Interferon Cytokine Res 18(7): 439-50.
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