Oligo GEArray® Human Genome Stability / DNA Repair Microarray

HybTube Format Cat. No.: OHS-042
HybPlate Format Cat. No.: EHS-042 		 
Description
The Oligo GEArray® Human Genome Stability and DNA Repair Microarray profiles the expression of 113 genes related to the maintenance of genome stability. Genes involved in base-excision, nucleotide excision, and mismatch repair processes are included. This array also contains genes involved in double-strand break (DSB) repair and the RAD6-dependent pathway. The key genes involved in genome stability and telomere maintenance are also represented. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples.

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Functional Gene Grouping

DNA Damage Repair:

Base Excision Repair (BER): APEX1, APEX2, FLJ10858, LIG3, MBD4, MPG, MUTYH, NEIL1, NEIL2, NTHL1, OGG1, PARP1, PARP3, SMUG1, TDG, UNG, UNG2, XRCC1.

Nucleotide Excision Repair (NER): ATXN3, BRIP1, CCNH, CDK7, CETN2, CKN1, DDB1, DDB2, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, GTF2H1, GTF2H2, GTF2H3, GTF2H4, LIG1, MMS19L, MNAT1, PNKP, POLL, RAD23A, RAD23B, RPA1, RPA3, SLK, XAB2, XPA, XPC.

Mismatch Repair (MMR): ANKRD17, MLH1, MLH3, MSH2, MSH3, MSH4, MSH5, MSH6, N4BP2, PMS1, PMS2, PMS2L1, PMS2L9, POLD3, TP73, TREX1.

Double-Strand Break (DSB) Repair: BRCA1, BRCA2, CIB1, DMC1, FEN1, G22P1, KUB3, LIG4, MRE11A, NBS1, PRKDC, RAD21, RAD50, RAD51, RAD51C, RAD51L1, RAD51L3, RAD52, RAD54B, RAD54L, XRCC2, XRCC3, XRCC4, XRCC5.

RAD6-dependent Pathway: RAD18, UBE2A, UBE2B, UBE2I, UBE2N, UBE2V2.

Other Genes Related to DNA-repair: ATM, ATR, EXO1, MGMT, TERF2, TERT.

Genome Stability:

Telomere Maintenance: DKC1, MRE11A, PINX1, RAD50, RFC1, TEP1, TERF1, TERF2, TERF2IP, TERT, TINF2, TNKS, TNKS1BP1, TNKS2.

Other Genes Related to Genome Stability: ATM, TOP3A, TOP3B.

Storage Conditions
Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References
  1. Trends in Biochemical Sciences (TIBS) 20 (10): October 1995 (237): 381-440
  2. Friedberg, E.C., Walker, G.C., and Siede, W. DNA repair and mutagenesis, Washington, D.C.ASM Press, 1995: 1-698.
  3. Hoege, C., B. Pfander, et al. (2002). RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419 (6903): 135-41.
  4. Richard D. Wood, Michael Mitchell, John Sgouros, Tomas Lindahl. (2001). Human DNA Repair Genes. Science 291:1284-1289.
  5. de Wind, N. and J. B. Hays (2001). Mismatch repair: praying for genome stability. Curr Biol 11 (14): R545-8.
  6. Ronen, A. and B. W. Glickman (2001). Human DNA repair genes. Environ Mol Mutagen 37 (3): 241-83.
  7. JAN H. J. HOEIJMAKERS (2001). Genome maintenance mechanisms for preventing cancer. Nature 411, 366-374.
  8. McEachern, M. J., Krauskopf, A. & Blackburn, E. H. (2000). Telomeres and their control. Annu. Rev. Genet. 34, 331-358.
  9. Haber, J. E. (2000). Partners and pathways repairing a double-strand break. Trends Genet. 16, 259-264
  10. Scully, R. & Livingston, D. M. (2000). In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408, 429-432.
  11. Khanna, K. K. & Jackson, S. P. (2001). DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genet. 27, 247-254.
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