Oligo GEArray® Human Cancer PathwayFinder Microarray

HybTube Format Cat. No.: OHS-033
HybPlate Format Cat. No.: EHS-033 		 
Description
The Oligo GEArray® Human Cancer PathwayFinder™ Microarray profiles the expression of 113 genes representative of the six biological pathways involved in transformation and tumorigenesis listed below. Through a simple side-by-side hybridization experiment you can simultaneously determine which of the 6 pathways is involved in your experimental treatment. Once you have identified the pathways involved in your treatment with this microarray, you can then perform focused profiling experiments using our pathway-specific GEArray® Microarrays. Through a simple side-by-side hybridization experiment you can determine differential gene expression between your samples.

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Related Products for the Genes on This Array
shRNA Plasmids qPCR Gene Assays Modify This Array
Functional Gene Grouping

Cell Cycle Control & DNA Damage Repair: ATM, BRCA1, BRCA2, CCND1 (cyclin D1), CCNE1 (cyclin E1), CDC25A, CDK2, CDK4, CDKN1A (p21Waf1), CDKN1B (p27Kip1), CDKN2A (p16Ink4), CHEK2 (chk2 / Rad53), E2F1, MDM2, PRKDC (DNA-PK), PTEN, S100A4, RB1, TP53 (p53).

Apoptosis and Cell Senescence: APAF1, BAD, BAX, BCL2, BCL2L1 (bcl-X), BIRC5 (Survivin), CASP8, CASP9, CFLAR (CASPER), GZMA, HTATIP2, TERT (telomerase), TNFRSF1A (TNF-a receptor), TNFRSF6 (Fas), TNFRSF10B (DR5), TNFRSF25 (DR3).

Signal Transduction Molecules and Transcription Factors: AKT1, CTNNB1 (β-catenin), ERBB2, ETS2, FOS, JUN, MAPK14 (p38 MAPK), MAP2K1 (MEK), MYC, NFKB1 (NFκB), NFKBIA (IκBα), PIK3CB (PI3K p110b), PIK3R1 (PI3K p85α), RAF1, RASA1, SNCG, SRC.

Adhesion: CD44, CDH1 (E-cadherin), ICAM1, ITGA1 (integrin a1), ITGA2 (integrin a2), ITGA3 (integrin a3), ITGA4 (integrin a4), ITGA5 (integrin a5), ITGA6 (integrin a6), ITGAV (integrin aV), ITGB1 (integrin ?1), ITGB3 (integrin ?3), ITGB5 (integrin ?5), MCAM, MICA (MUC18), MTSS1, NCAM1, PNN, SYK, UCC1.

Angiogenesis: ANGPT1 (angiopoietin-1), ANGPT2 (angiopoietin-2), BAI1, COL18A1 (endostatin), EGF, EGFR, FGF2 (bFGF), FGFR2, FLT1 (VEGFR), HGF, IFNA1 (IFNa), IFNB1 (IFN?), IGF1, IL8, PDGFA, PDGFB, TEK (tie-2), TGFB1, TGFBR1 (ALK-5), THBS1 (thrombospondin-1), THBS2 (thrombospondin-2), TNF, VEGF.

Invasion and metastasis: KISS1, KAI1, MET, MMP1 (collagenase-1), MMP2 (gelatinase A), MMP9 (gelatinase B), MTA1, MTA2, NME1, NME4 (Nm23), PLAU, PLAUR, S100A4, SERPINB2 (PAI2), SERPINB5 (maspin), SERPINE1 (PAI1), TIMP1, TIMP3, TWIST1.

Storage Conditions
Please check the kit components immediately after you receive this package. SABiosciences is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References
  1. Hanahan, D. and Weinberg, R.A. (2000) The Hallmarks Of Cancer. Cell 100: 57-70.
  2. Tsatsanis, C. and Spandidos, D.A. (2000) The Role Of Oncogenic Kinases In Human Cancer. Int J Mol Med 5: 583-590.
  3. Meyer, T. and Hart, I.R. (1998) Mechanisms Of Tumour Metastasis. Eur J Cancer 34: 214-221.
  4. Detmar, M. (2000) Tumor Angiogenesis. JID Symposium Proceedings 5: 20-23.
  5. Klingelhutz, A.J. (1999) The Roles Of Telomeres And Telomerase In Cellular Immortalization And The Development Of Cancer. Anticancer Res 19: 4823-4830.
  6. Kaufmann, S.H. and Gores, G.J. (2000) Apoptosis In Cancer: Cause And Cure. BioEssays 22: 1007-1017.
  7. Lowe, S.W. and Lin, A.W. (2000) Apoptosis In Cancer. Carcinogenesis 21: 485-495.
  8. Funk, J.O. (1999) Cancer Cell Cycle Control. Anticancer Res 19: 4772-4780.
  9. Molinari, M. (2000) Cell Cycle Checkpoints And Their Inactivation In Human Cancer. Cell Prolif 33: 261-274.
  10. Clezardin, P. (1998) Recent Insights Into The Role Of Integrins In Cancer Metastasis. Cell Mol Life Sci 54: 541-548.
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