| Description |
| GEArray® Q Series Androgen Signaling and Prostate Cancer Gene Array is designed to assess the role of 96 genes in androgen-regulated processes that are involved in malignant transformation of prostate gland. Androgen signaling plays an important role in the pathogenesis of prostate cancer, as exemplified by androgen ablation therapy for advanced prostate cancer. Activation of the PI3K/AKT/FRAP pathway has also been found to contribute to hormone resistant growth of recurrent prostate cancer. On the Androgen Signaling and Prostate Cancer Gene Array, 96 prostate cancer-related genes have been grouped into the following categories: androgen receptor and androgen receptor-associated proteins, androgen exclusively-responsive genes, androgen-independent genes, target genes whose responsiveness to androgen changes during the course of prostate malignant transformation, PI3K/AKT/FRAP pathway related genes that are associated with hormone-refractory cell growth, and genes associated with invasive prostate cancer.
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Functional Gene Grouping |
- Androgen receptor and associated proteins:
- Ar, Ncoa4 (Rfg), Nsd1 (ARA267), PAK6-ESTs, Ran (ARA24), Rnf14 (ARA54), Tgfb1i1 (ARA55), Tmf1-ESTs
- Androgen-responsive prostate cancer-related genes:
- Androgen receptor & associated proteins: Ncoa4, Pak6-ESTs, Tmf1-ESTs (ARA160)
- Proteases and Enzymes: 2010301M18Rik (Cyp2c19), Acpp, Adh1, Akr1b3 (aldose reductase), Aldh1a1 (ALDH1), Dhcr24 (seladin-1), Folh1 (PSMA), Gpx5, Klk4, Morf-pending, Myst1, Ngfa, Ppap2a, Ppap2b, Srd5a2, Tgm4 (hTGP), Tmprss2
- Transcriptional factors/DNA-binding proteins:
- Calr, CHD4-ESTs, Fgf8, Hmg20b, LOC217166 (Nr1d1), LOC234593 (Ndrg), Ndr1, Nkx3-1 (NKX3.1), Pse-pending, Shbg, Srebf1, Srebf2, Thra, Trim28 (KAP1/TIF1beta)
- Genomic maintenance and cell cycle regulation:
- Bcrp1-pending (BAF), Csnk2b, Ei24 (Pig8), Impdh2, Odc, Pcna, Xrcc2
- Androgen-independent prostate cancer-related genes:
- Anxa7, Apoe, Cdh1, Enh-pending (Lim), Gstp1, Hpn (Hepsin), Olfr78 (PSGR), Pov1, Psca, Pten, Ptov1, Sparcl1 (HEVIN), Steap, Tnfrsf6 (FAS)
- Genes switched from androgen responsive to androgen independent in recurrent prostate cancer after hormone therapy:
- Adam9, Adm, Ldh1, Mdt1, Mor2, Odc, Pcna
- PI3K/AKT/FRAP pathway related genes that were associated with hormone-refractory cell growth:
- AW125888 (Cds1), Ccnd1, Eif4ebp1, Fkbp5 (AIG6), Fkbp8, Foxj1, Mapkapk2, Nfkbia, Odc
- Genes associated with invasive prostate cancers:
- C20orf1-Rik (FLS353), Fat, Fbxl11, Igf1, Igfbp5, Kcnmb1, Mta1, Mybl2, Oxr1 (C7), Ppap2b, Rab5a, Rap1a, Sfrp4
- Other Related Genes:
- Ank, Cdc37, Clu, Cstb, Dbi, Falpalpha, Hoxb13, Jtb (PAR), N4wbp4-pending, Slc21a11, V1rc7, Vti1b
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| Storage Conditions |
| Please check the kit components immediately after you receive this package. SuperArray is only responsible for missing items reported within two (2) business days of receipt. GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.
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| References |
- Luo JH, Yu YP, Cieply K, Lin F, Deflavia P, Dhir R, Finkelstein S, Michalopoulos G, Becich M. Gene expression analysis of prostate cancers. Mol Carcinog 2002 Jan; 33 (1): 25-35
- Mousses S, Wagner U, Chen Y, Kim JW, Bubendorf L, Bittner M, Pretlow T, Elkahloun AG, Trepel JB, Kallioniemi OP. Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling. Oncogene 2001 Oct 11; 20 (46): 6718-23
- Xu LL, Su YP, Labiche R, Segawa T, Shanmugam N, McLeod DG, Moul JW, Srivastava S. Quantitative expression profile of androgen-regulated genes in prostate cancer cells and identification of prostate-specific genes. Int J Cancer 2001 May 1; 92 (3): 322-8
- Dhanasekaran SM, Barrette TR, Ghosh D, Shah R, Varambally S, Kurachi K, Pienta KJ, Rubin MA, Chinnaiyan AM. Delineation of prognostic biomarkers in prostate cancer. Nature 2001 Aug 23; 412 (6849): 822-6
- Bull JH, Ellison G, Patel A, Muir G, Walker M, Underwood M, Khan F, Paskins L. Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray. Br J Cancer 2001 Jun 1; 84 (11): 1512-9
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