GEArray® Q Series Human Diabetes Gene Array: HS-050
  
Description
Diabetes is a disorder of metabolism that manifests itself in two ways. Type I or inherited diabetes destroys the insulin-producing beta-islet cells of the pancreas. Type II diabetes, caused by insulin resistance, develops later in life and is an increasingly common disorder of carbohydrate and lipid metabolism. It affects 16 million people in the United States with 800,000 new cases identified every year. Inflammation, glucose and lipid metabolism, and adipocytes (fat cells) have recently been shown to play key roles in this pathophysiological condition. The GEArray® Q Series Human Diabetes Gene Array contains 96 genes important in the onset, development, and progression of diabetes. They include genes that contribute to obesity, insulin resistance, the early onset of diabetes, and complications from diabetes mellitus. These genes are grouped into six functional categories: receptors, transporters & channels; nuclear receptors; metabolic enzymes; secreted factors; signal transduction proteins; and transcription factors. Many of the genes included have a tissue-specific or tissue-biased expression pattern; however, different pathophysiological states can change those patterns. Therefore, this array can be used to further study models of obesity and diabetes, to screen for therapeutics and their targets, and to profile the effect of various epidemiological and environmental factors on the expression of these genes in various tissues or cell lines.

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Receptors, Transporters & Channels: ABCC8, ADRB3, AQP2, CD28, CEACAM1, CTLA4, GCGR, GLP1R, HLA-DQB1, HLA-DRB5, ICAM1, IL4R, INSR, NSF, RAB4A, SELL (LECAM-1), SLC2A4 (GLUT4), SNAP23, SNAP25, STX4A, STXBP1, STXBP2, STXBP4, TNFRSF1A, TNFRSF1B, VAMP3, VAPA, VAPB.

Nuclear Receptors: PPARA, PPARG.

Metabolic Enzymes: ACE, ACLY, ADPRT, ENPP1, FBP1, G6PC, G6PD, GCK, GPD1, GSK3B, HMOX1, IDE, ME1, NOS3, PCK1, PFKFB3, PRKAA1, PRKAG2, PYGL.

Secreted Factors: AGT, CCL5 (Rantes), CCR2 (MCP-1), GCG, IFNG, IL6, IL10, IL12B, INS, RETN, TGFB1, TNF, VEGF.

Signal Transduction: AKT2, C20orf97, DUSP4, IGFBP5, IKBKB (IKKbeta), INPPL1 (SHIP2), IRS1, IRS2, MAP2K3, MAP2K6, MAPK8 (JNK1), MAPK14 (p38 MAPK), PIK3C2B, PIK3CD, PIK3R1, PRKCB1, PTPN1 (PTP-1B).

Transcription Factors: CEBPA, CEBPB, FOXC2, FOXG1B, FOXP3, HNF4A, IPF1 (PDX-1), NEUROD1, NFKB1, NRF1, PAX4, PPARGC1A, PPARGC1B, SREBF1, SREBF2, TCF2 (HNF1b), TITF1.
Storage Conditions
Please check the kit components immediately after you receive this package. SuperArray is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References
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