GEArray® Q Series Human Extracellular Matrix and Adhesion Molecules Gene Array: HS-010
  
Description
The GEArray® Q Series Human Extracellular Matrix & Adhesion Molecules Gene Array contains 96 genes encoding proteins important for the attachment of cells to their surroundings. As seen in the list below, the array includes various types of cell adhesion molecules (such as the intregrins, IgG superfamily members, cadherins and catenins, and selectins) as well as extracellular matrix proteins, proteases (such as the matrix metalloproteinases and the serine and cysteine proteinases) and their inhibitors. These proteins play key roles in mediating cell-cell, cell-tissue and cell-extracellular matrix interactions and are involved in the normal processes of cell growth, division, differentiation, migration, as well as apoptosis. These genes are also important in many diseases and pathophysiological processes, including tumor invasion and metastasis, rheumatoid arthritis, cardiovascular disorders, wound healing, inflammation, and some central nervous diseases. Through a simple side-by-side hybridization using your experimental RNA samples and the arrays and reagents provided in the kit, you can simultaneously determine the expression profile of these matrix and adhesion molecules in your model system.

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Useful Links
User Manual Gene Table shRNA Plasmids
Pricing and Ordering PCR Primers
Functional Gene Grouping

Cell Adhesion Molecules:

Integrins: ITGA1 (integrin a1), ITGA2 (integrin a2/ LFA1b), ITGA2B (integrin a2b), ITGA3 (integrin a3), ITGA4 (integrin a4 /VLA-4), ITGA5 (integrin a5), ITGA6 (integrin a6), ITGA7 (integrin a7), ITGA8 (integrin a8), ITGA9 (integrin a9), ITGA10 (integrin a10), ITGA11 (integrin a11), ITGAL (integrin aL / LFA1a /CD11A), ITGAM (integrin aM), ITGAV (integrin aV), ITGAX (integrin aX), ITGB1 (integrin b1), ITGB2 (integrin b2), ITGB3 (integrin b3 / CD61), ITGB4 (integrin b4), ITGB5 (integrin b5), ITGB6 (integrin b6), ITGB7 (integrin b7), ITGB8 (integrin b 8).

Immunoglobulin (Ig) Superfamily: CEACAM5 (CEA), DCC, ICAM1, MICA (MUC-18), NCAM1, NRCAM, PECAM1, VCAM1.

Cadherin and Catenins: CDH1 (E-cadherin), CTNNA1 (catenin a), CTNNAL1 (catenin a like 1), CTNNB1 (catenin b), CTNND1 (catenin d1), CTNND2 (catenin d 2).

Selectins: SELE (ELAM-1/E-selectin), SELL (L-selectin), SELP (P-selectin).

Other Related Genes: CD44, CNTN1.

Extracellular Matrix Proteins:

CAV1 (caveolin-1), COL18A1 (LOC51695 / endostatin), COL1A1, COL4A2, ECM1, FGB (fibrinogen b ), FN1 (fibronectin-1), LAMB1 (laminin B1), LAMC1 (laminin B2), SPARC, SPP1 (OPN, osteopontin), THBS1 (TSP-1), THBS2 (TSP-2), THBS3 (TSP-3), VTN (vitronectin).

Proteases:

Matrix Metalloproteinases: ADAMTS1 (Meth 1), ADAMTS8 (Meth 2), MMP1 (collagenase-1), MMP2 (gelatinase A), MMP3 (stromelysin-1), MMP7 (matrilysin), MMP8 (neutrophil collagenase), MMP9 (gelatinase B), MMP10 (stromelysin-2), MMP11 (stromelysin-3), MMP12 (macrophage elastase), MMP13 (collagenase-3), MMP14 (MT1-MMP), MMP15, MMP16, MMP17, MMP20 (enamelysin), MMP24, MMP26.

Serine Proteinases: CTSG (cathepsin G), PLAT (tPA), PLAU (uPA), PLAUR (uPAR), TMPRSS4.

Cysteine Proteinases: CASP8, CASP9, CST3 (cystatin C), CTSB (cathepsin B), CTSL (cathepsin L).

Other Related Genes: CTSD (cathepsin D), HPSE (heparanase), MGEA5 (meningioma assoc. hyaluronidase).

Protease Inhibitors: SERPINB2 (PAI-2), SERPINB5 (maspin), SERPINE1 (PAI-1), TIMP1, TIMP2, TIMP3.
Storage Conditions
Please check the kit components immediately after you receive this package. SuperArray is only responsible for missing items reported within two (2) business days of receipt.

GEArray microarrays are shipped at ambient temperature enclosed in either a HybTube or ExpressPak Storage Box. They should be stored at -20 ºC upon receipt.

References
  1. Mignatti P, Rifkin DB. (2000) Non-enzymatic Interactions Between Proteinases And The Cell Surface: Novel Roles In Normal And Malignant Cell Physiology. Adv Cancer Res. 78 : 103-57.
  2. Gumbiner BM (1996). Cell Adhesion: The Molecular Basis Of Tissue Architecture And Morphogenesis. Cell 84 : 345-357.
  3. Ben-Ze'ev A, Geiger, B (1998) Differential Molecular Interactions Of b -Catenin And Plakoglobin In Adhesion, Signaling And Cancer. Curr. Opin. Cell Biol. 10 : 629-639.
  4. Ohene-Abuakwa Y, Pignatelli M (2000) Adhesion Molecules In Cancer Biology. Adv Exp Med Biol 465 : 115-126.
  5. Lo CW (1999) Genes, Gene Knockouts, And Mutations In The Analysis Of Gap Junctions. Dev. Genet. 24 : 1-4.
  6. Burridge K., and M. Chrzanowska-Wodnicka. 1996. Focal Adhesions, Contractility, And Signaling. Ann. Rev. Cell Dev. Biol. 12 : 463-519.
  7. Clezardin P (1998) Recent Insights Into The Role Of Integrins In Cancer Metastasis. Cell Mol Life Sci 54: 541-548.
  8. Werb, Z. (1997) ECM and Cell Surface Proteolysis: Regulating Cellular Ecology. Cell 91 : 439-442.
  9. Johansson N, et al. (2000) Matrix Metalloproteinases in Tumor Invasion. Cell Mol Life Sci 57 : 5-15.
  10. Zieske JD (2001) Extracellular Matrix and Wound Healing Curr Opin Ophthalmol 12 : 237-41.
  11. Sobel RA. (2001) The Extracellular Matrix in Multiple Sclerosis: An Update. Braz J Med Biol Res 34 : 603-9.
  12. Schonherr E, Hausser HJ (2000) Extracellular Matrix and Cytokines: a Functional Unit. Dev Immunol 7 : 89-101.
  13. Raines EW. (2000) The Extracellular Matrix Can Regulate Vascular Cell Migration, Proliferation, and Survival: Relationships to Vascular Disease. Int J Exp Pathol. 81 : 173-82.
  14. Boluyt MO, Bing OH (2000) Matrix Gene Expression and Decompensated Heart Failure: the Aged SHR Model. Cardiovasc Res. 46: 239-49.
  15. Streuli C (1999) Extracellular Matrix Remodelling and Cellular Differentiation. Curr Opin Cell Biol. 11: 634-40
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